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133
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16102 |
ML-792
|
E1/E2/E3 Enzyme | Ubiquitination |
ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2,IC50分别为 3 和 11 nM,对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱,IC50分别为 32 μM 和 >100 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01021 |
SUMO3 Protein, Human, Recombinant
SMT3H1,SMT3 Homolog 1,SUMO3 |
Human | E. coli |
SUMO3 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 KDa and the accession number is P55854. | |||
TMPJ-01022 |
SUMO3 Protein, Human, Recombinant (HEK293, His)
SMT3 homolog 1,Smt3A,Small ubiquitin-relat... |
Human | HEK293 Cells |
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect... | |||
TMPJ-01023 |
SUMO3 Protein, Human, Recombinant (E.coli, His)
Ubiquitin-Like Protein SMT3B,SMT3H1,SU... |
Human | E. coli |
SUMO3 Protein, Human, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is P55854. | |||
TMPJ-00486 |
SUMO2 Protein, Human, Recombinant (His)
HSMT3,Ubiquitin-Like Protein SMT3A,SUM... |
Human | E. coli |
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and l... | |||
TMPH-02298 |
Urocortin-3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. | |||
TMPH-02145 |
MMP-3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. | |||
TMPH-01669 |
Metallothionein-3/MT3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. | |||
TMPH-02473 |
14-3-3 zeta/delta Protein, Mouse, Recombinant (His & SUMO)
Ywhaz,14-3-3 protein zeta/delta,SEZ-2,KCIP... |
Mouse | E. coli |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. 14-3-3 zeta/delta Prot... | |||
TMPH-01924 |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00459 |
Dac g 3 Protein, Dactylis glomerata, Recombinant (His & SUMO)
Pollen allergen Dac g 3,Allergen Dac g III,Dac g |
Dactylis glomerata | E. coli |
Dac g 3 Protein, Dactylis glomerata, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00198 |
Bet v 3 Protein, Betula pendula, Recombinant (His & Myc & SUMO)
Bet v 3,Allergen Bet v III,BETVIII,Calcium-binding ... |
Betula pendula | E. coli |
Could be involved in calcium metabolism in pollen. Binds 3 calcium ions. Bet v 3 Protein, Betula pendula, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 43.1 kDa and the accession number is P43187. | |||
TMPH-01105 |
ST3GAL3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. ST3GAL3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.9 kDa and the accession nu... | |||
TMPH-03543 |
Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)
SEC3,entC3,Enterotoxin type C-3 |
Staphylococcus aureus | E. coli |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPH-02796 |
NLRP3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
NLRP3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.2 kDa and the accession number is Q8R4B8. | |||
TMPH-00839 |
RIPK3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
RIPK3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.9 kDa and the accession number is Q9Y572. | |||
TMPH-03250 |
NPR3 Protein, Rat, Recombinant (His & SUMO)
|
Rat | E. coli |
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system wi... | |||
TMPH-01697 |
MORC3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in vitro. May be required for influenza A transcription during viral infection. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is ... | |||
TMPH-01176 |
CSRP3 Protein, Human, Recombinant (His & SUMO)
CLP,CRP,Muscle LIM protein,CSRP3,Cardiac LIM protei... |
Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01235 |
APOBEC3A Protein, Human, Recombinant (His & SUMO)
A3A,APOBEC3A,DNA dC->dU-editing enzyme APO... |
Human | E. coli |
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a rol... | |||
TMPH-02535 |
BAG3 Protein, Mouse, Recombinant (His & SUMO)
Bcl-2-associated athanogene 3,Bis,BAG-3,BA... |
Mouse | E. coli |
BAG3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 77.7 kDa and the accession number is Q9JLV1. | |||
TMPH-02325 |
ZP3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. ZP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.6 kDa and the accession n... | |||
TMPH-02865 |
Wnt3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. | |||
TMPH-01096 |
CELA3A Protein, Human, Recombinant (His & SUMO)
Elastase-3A,Protease E,ELA3,Chymotrypsin-l... |
Human | E. coli |
Efficient protease with alanine specificity but only little elastolytic activity. CELA3A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.6 kDa and the accession number is P09093. | |||
TMPH-01964 |
YPEL3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
YPEL3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02516 |
APOC3 Protein, Mouse, Recombinant (His & SUMO)
APOC3,ApoC-III,Apolipoprotein C3,Apolipopr... |
Mouse | E. coli |
APOC3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.9 kDa and the accession number is P33622. | |||
TMPH-01274 |
ZNRF3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... | |||
TMPH-01358 |
FXYD3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
FXYD3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 20.5 kDa and the accession number is Q14802. | |||
TMPH-00948 |
APOC3 Protein, Human, Recombinant (His & SUMO)
Apolipoprotein C3,Apo-CIII,Apolipoprotein C-III,APO... |
Human | E. coli |
APOC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.8 kDa and the accession number is P02656. | |||
TMPH-01730 |
MYBPC3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896. | |||
TMPH-02226 |
TEAD3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr... | |||
TMPH-02117 |
SPRR3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Cross-linked envelope protein of keratinocytes. SPRR3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.0 kDa and the accession number is Q9UBC9. | |||
TMPH-02954 |
TNNI3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.1 kDa and the accession number is P48787. | |||
TMPH-01621 |
BRCC3 Protein, Human, Recombinant (His & SUMO)
BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/... |
Human | E. coli |
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta... | |||
TMPH-01473 |
HDAC3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
HDAC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.8 kDa and the accession number is O15379. | |||
TMPH-01253 |
DCTN3 Protein, Human, Recombinant (His & SUMO)
DCTN22,Dynactin complex subunit 22 kDa subunit (p22),Dynacti... |
Human | E. coli |
Together with dynein may be involved in spindle assembly and cytokinesis. DCTN3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.3 kDa and the accession number is O75935. | |||
TMPH-01393 |
GRIA3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
GRIA3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.0 kDa and the accession number is P42263. | |||
TMPH-02650 |
FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | |||
TMPH-01762 |
CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO)
CHRNA3,NACHRA3,Neuronal acetylcholine rece... |
Human | E. coli |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 44.6 kDa and the accession number is P32297. | |||
TMPH-02604 |
Complement C3 Protein, Mouse, Recombinant (His & SUMO)
C3,Complement C3 |
Mouse | E. coli |
Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession number is P01027. | |||
TMPH-02896 |
Serpin A3N Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Serpin A3N Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 60.8 kDa and the accession number is Q91WP6. | |||
TMPH-00231 |
Complement C3 Protein, Bovine, Recombinant (His & SUMO)
Complement C3,C3 |
Bovine | E. coli |
Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.5 kDa and the accession number is Q2UVX4. | |||
TMPH-02450 |
MALD3 Protein, Malus domestica, Recombinant (His & SUMO)
|
Apple | E. coli |
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues. MALD3 Protein, Malus domestica, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 25.1 kDa and the accession number is Q9M5X7. | |||
TMPH-03710 |
Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO)
|
Viscum album | E. coli |
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 20.8 kDa and the accession number is P01538. | |||
TMPH-01310 |
EIF3G Protein, Human, Recombinant (His & SUMO)
eIF3 p42,eIF-3-delta,eIF3 p44,eIF... |
Human | E. coli |
EIF3G Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.5 kDa and the accession number is O75821. | |||
TMPH-01311 |
EIF3M Protein, Human, Recombinant (His & SUMO)
HFLB5,eIF3m,EIF3M,hFL-B5,Eukaryotic transl... |
Human | E. coli |
EIF3M Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 58.4 kDa and the accession number is Q7L2H7. | |||
TMPH-01622 |
KDM3B Protein, Human, Recombinant (His & Myc & SUMO)
|
Human | E. coli |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. | |||
TMPH-02288 |
UBE2D3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
UBE2D3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.7 kDa and the accession number is P61077. | |||
TMPH-01480 |
H2BC3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
H2BC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01250 |
MAP2K3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. MAP2K3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession numbe... | |||
TMPH-03054 |
Asp f3 Protein, Neosartorya fumigata, Recombinant (His & SUMO)
|
Neosartorya fumigata | E. coli |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Required for virulence. | |||
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